Diastereoselective Decarboxylative Alkynylation of Anomeric Carboxylic Acids Using Cu/Photoredox Dual Catalysis

Alkynyl C-nucleosides are of high value for various applications; however, their synthesis remains underexplored. Here we report a simple route toward the synthesis of alkynyl C-nucleosides from simple and stable furanosyl carboxylic acids and terminal alkynes under low-cost and nontoxic copper catalysis. The approach that we report here demonstrates the power of Cu/photoredox dual catalysis to access highly complex glycosides under mild conditions.