Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings

Laurent El Kaim; Marie Gizolme; Laurence Grimaud; Julie Oble

doi:10.1021/ol061605o

Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings

Laurent El Kaim
, Marie Gizolme
, Laurence Grimaud
, Julie Oble

Unité Chimie et Procédés

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

90 Citations (Scopus)

Résumé

New heterocyclic scaffolds can be easily prepared by the coupling of heteroaromatic phenols (pyridines, pyrimidines) with carbonyl compounds, amines, and isocyanides. This transformation related to the Ugi reaction probably involves a Smiles rearrangement. The scope of this methodology is further extended by the successful use of heterocyclic thiols to form highly functionalized thioamides.

langue originale	Anglais
Pages (de - à)	4019-4021
Nombre de pages	3
journal	Organic Letters
Volume	8
Numéro de publication	18
Les DOIs	https://doi.org/10.1021/ol061605o
état	Publié - 31 août 2006
Modification externe	Oui

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10.1021/ol061605o

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title = "Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings",

abstract = "New heterocyclic scaffolds can be easily prepared by the coupling of heteroaromatic phenols (pyridines, pyrimidines) with carbonyl compounds, amines, and isocyanides. This transformation related to the Ugi reaction probably involves a Smiles rearrangement. The scope of this methodology is further extended by the successful use of heterocyclic thiols to form highly functionalized thioamides.",

author = "\{El Kaim\}, Laurent and Marie Gizolme and Laurence Grimaud and Julie Oble",

year = "2006",

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T1 - Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings

AU - El Kaim, Laurent

AU - Gizolme, Marie

AU - Grimaud, Laurence

AU - Oble, Julie

PY - 2006/8/31

Y1 - 2006/8/31

N2 - New heterocyclic scaffolds can be easily prepared by the coupling of heteroaromatic phenols (pyridines, pyrimidines) with carbonyl compounds, amines, and isocyanides. This transformation related to the Ugi reaction probably involves a Smiles rearrangement. The scope of this methodology is further extended by the successful use of heterocyclic thiols to form highly functionalized thioamides.

AB - New heterocyclic scaffolds can be easily prepared by the coupling of heteroaromatic phenols (pyridines, pyrimidines) with carbonyl compounds, amines, and isocyanides. This transformation related to the Ugi reaction probably involves a Smiles rearrangement. The scope of this methodology is further extended by the successful use of heterocyclic thiols to form highly functionalized thioamides.

U2 - 10.1021/ol061605o

DO - 10.1021/ol061605o

M3 - Article

AN - SCOPUS:33748921576

SN - 1523-7060

VL - 8

SP - 4019

EP - 4021

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings

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