DOTASQ as a prototype of nature-inspired G-quadruplex ligand

Loic Stefan; Aurore Guédin; Samir Amrane; Nicole Smith; Franck Denat; Jean Louis Mergny; David Monchaud

doi:10.1039/c0cc04960c

DOTASQ as a prototype of nature-inspired G-quadruplex ligand

Loic Stefan
, Aurore Guédin
, Samir Amrane
, Nicole Smith
, Franck Denat
, Jean Louis Mergny
, David Monchaud

UBFC
Univ. Bordeaux

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

58 Citations (Scopus)

Résumé

DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).

langue originale	Anglais
Pages (de - à)	4992-4994
Nombre de pages	3
journal	Chemical Communications
Volume	47
Numéro de publication	17
Les DOIs	https://doi.org/10.1039/c0cc04960c
état	Publié - 7 mai 2011
Modification externe	Oui

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10.1039/c0cc04960c

Contient cette citation

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AU - Amrane, Samir

AU - Smith, Nicole

AU - Denat, Franck

AU - Mergny, Jean Louis

AU - Monchaud, David

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DOTASQ as a prototype of nature-inspired G-quadruplex ligand

Résumé

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