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Dynamics of a kinetic model describing protein transfers in a cell population

  • IMB UMR 5251

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Résumé

We consider a cell population structured by a positive real number x∈R+, which represents the number of P-glycoproteins carried by the cell. These proteins combine two interesting properties: they are involved in the resistance of cancer cells to chemotherapy drugs, and the cells undergo frequent transfers of those proteins. In this article, we introduce a kinetic model to describe the dynamics of the cell population. We then consider an asymptotic limit of this equation: if transfers are frequent, the population can be described through a system of two coupled ordinary differential equations. Finally, we show that the solutions of the kinetic model converge to a unique steady-state in large times. The main idea of this manuscript is to combine Wasserstein distance estimates on the kinetic operator with more classical estimates on the macroscopic quantities.

langue originaleAnglais
Numéro d'article76
journalJournal of Mathematical Biology
Volume91
Numéro de publication6
Les DOIs
étatPublié - 1 déc. 2025

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