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Effect of lecithin on dermal safety of nanoemulsion prepared from hydrogenated lecithin and silicone oil

  • Duck Hwan Bae
  • , Jae Sup Shin
  • , Gwi Su Shin
  • , Fan Long Jin
  • , Soo Jin Park
  • Chungbuk National University
  • Jeonbuk Regional Innovation Agency
  • Jilin Institute of Chemical Technology
  • Inha University

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

Résumé

In this study, a hydrogenated lecithin-containing nanoemulsion was prepared from hydrogenated lecithin and silicone oil. Tween-60 and liquid paraffin, widely known emulsifiers, were used as standard substances, and high shear was produced by utilizing a high shear homogenizer and microfluidizer. The properties of the nanoemulsion prepared with hydrogenated lecithin were evaluated by measuring interfacial tension, dynamic interfacial tension, droplet size, zeta-potential, friction force, skin surface hygrometery, and dermal safety. The interfacial tension of lecinol S10/silicone oil was lower than that of lecinol S10/liquid paraffin. The nanoemulsion prepared from hydrogenated lecithin shows lower zeta-potential, skin surface hygrometery, and friction force compared with a general emulsion. The silicone nanoemulsion prepared from hydrogenated lecithin showed a zero value in the patch test and thus exhibits high dermal safety.

langue originaleAnglais
Pages (de - à)821-824
Nombre de pages4
journalBulletin of the Korean Chemical Society
Volume30
Numéro de publication4
Les DOIs
étatPublié - 1 janv. 2009
Modification externeOui

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