Efficient synthesis of the corticosteroid side-chain from 17-ketones

Derek H.R. Barton; William B. Motherwell; Samir Z. Zard

doi:10.1039/c39810000774

Efficient synthesis of the corticosteroid side-chain from 17-ketones

Derek H.R. Barton
, William B. Motherwell
, Samir Z. Zard

Institut de Chimie des Substances Naturelles

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphorate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.

langue originale	Anglais
Pages (de - à)	774-775
Nombre de pages	2
journal	Journal of the Chemical Society, Chemical Communications
Numéro de publication	15
Les DOIs	https://doi.org/10.1039/c39810000774
état	Publié - 1 janv. 1981
Modification externe	Oui

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10.1039/c39810000774

Contient cette citation

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title = "Efficient synthesis of the corticosteroid side-chain from 17-ketones",

abstract = "Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphorate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.",

author = "Barton, \{Derek H.R.\} and Motherwell, \{William B.\} and Zard, \{Samir Z.\}",

year = "1981",

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doi = "10.1039/c39810000774",

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journal = "Journal of the Chemical Society, Chemical Communications",

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N2 - Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphorate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.

AB - Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphorate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.

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DO - 10.1039/c39810000774

M3 - Article

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JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

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ER -

Efficient synthesis of the corticosteroid side-chain from 17-ketones

Résumé

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