Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path

Guillaume Giraud Collet; Nicola Festuccia; Pablo Navarro

doi:10.1016/j.xgen.2025.100919

Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path

Guillaume Giraud Collet
, Nicola Festuccia
, Pablo Navarro

Institut Pasteur
Laboratoire de Probabilités et Modèles Aléatoires

Résultats de recherche: Contribution à un journal › Commentaire/débat

Résumé

Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al.¹ studied RNA Pol II in bovine embryos and discovered super RNA Pol II domains, a regulatory architecture promoting transcription in species with delayed ZGA.

langue originale	Anglais
Numéro d'article	100919
journal	Cell Genomics
Volume	5
Numéro de publication	6
Les DOIs	https://doi.org/10.1016/j.xgen.2025.100919
état	Publié - 11 juin 2025
Modification externe	Oui

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10.1016/j.xgen.2025.100919

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title = "Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path",

abstract = "Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al.1 studied RNA Pol II in bovine embryos and discovered super RNA Pol II domains, a regulatory architecture promoting transcription in species with delayed ZGA.",

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AU - Navarro, Pablo

PY - 2025/6/11

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AB - Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al.1 studied RNA Pol II in bovine embryos and discovered super RNA Pol II domains, a regulatory architecture promoting transcription in species with delayed ZGA.

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DO - 10.1016/j.xgen.2025.100919

M3 - Comment/debate

AN - SCOPUS:105007444290

SN - 2666-979X

VL - 5

JO - Cell Genomics

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ER -

Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path

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