Enhancing 2-iodoxybenzoic acid reactivity by exploiting a hypervalent twist

Julius T. Su; William A. Goddard

doi:10.1021/ja054446x

Enhancing 2-iodoxybenzoic acid reactivity by exploiting a hypervalent twist

Julius T. Su
, William A. Goddard

Division of Chemistry and Chemical Engineering

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

A rearrangement of hypervalent bonds, or twisting, proves to be the rate-determining step in the 2-iodoxybenzoic acid (IBX) oxidation of alcohols. From this insight, derived from density functional theory calculations, we explain why IBX oxidizes large alcohols faster than small ones and propose a modification to the reagent predicted to make it more active.

langue originale	Anglais
Pages (de - à)	14146-14147
Nombre de pages	2
journal	Journal of the American Chemical Society
Volume	127
Numéro de publication	41
Les DOIs	https://doi.org/10.1021/ja054446x
état	Publié - 19 oct. 2005
Modification externe	Oui

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10.1021/ja054446x

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abstract = "A rearrangement of hypervalent bonds, or twisting, proves to be the rate-determining step in the 2-iodoxybenzoic acid (IBX) oxidation of alcohols. From this insight, derived from density functional theory calculations, we explain why IBX oxidizes large alcohols faster than small ones and propose a modification to the reagent predicted to make it more active.",

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AU - Goddard, William A.

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AB - A rearrangement of hypervalent bonds, or twisting, proves to be the rate-determining step in the 2-iodoxybenzoic acid (IBX) oxidation of alcohols. From this insight, derived from density functional theory calculations, we explain why IBX oxidizes large alcohols faster than small ones and propose a modification to the reagent predicted to make it more active.

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DO - 10.1021/ja054446x

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IS - 41

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Enhancing 2-iodoxybenzoic acid reactivity by exploiting a hypervalent twist

Résumé

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