ERM proteins and NF2 tumor suppressor: The Yin and Yang of cortical actin organization and cell growth signaling

Alexis Gautreau; Daniel Louvard; Monique Arpin

doi:10.1016/S0955-0674(01)00300-3

ERM proteins and NF2 tumor suppressor: The Yin and Yang of cortical actin organization and cell growth signaling

Alexis Gautreau
, Daniel Louvard
, Monique Arpin

Institut Curie

Résultats de recherche: Contribution à un journal › Article de révision › Revue par des pairs

164 Citations (Scopus)

Résumé

The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.

langue originale	Anglais
Pages (de - à)	104-109
Nombre de pages	6
journal	Current Opinion in Cell Biology
Volume	14
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/S0955-0674(01)00300-3
état	Publié - 1 févr. 2002
Modification externe	Oui

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10.1016/S0955-0674(01)00300-3

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abstract = "The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.",

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AB - The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.

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ERM proteins and NF2 tumor suppressor: The Yin and Yang of cortical actin organization and cell growth signaling

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