Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Canan G. Nebigil; Christiane Moog; Stéphan Vagner; Nadia Benkirane-Jessel; Duncan R. Smith; Laurent Désaubry

doi:10.1016/j.ejmech.2020.112653

Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Canan G. Nebigil
, Christiane Moog
, Stéphan Vagner
, Nadia Benkirane-Jessel
, Duncan R. Smith
, Laurent Désaubry

FMTS
CHRU Strasbourg
Institut Curie
Université Paris-Saclay
Université de Strasbourg
Institute of Molecular Biosciences, Mahidol University

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

langue originale	Anglais
Numéro d'article	112653
journal	European Journal of Medicinal Chemistry
Volume	203
Les DOIs	https://doi.org/10.1016/j.ejmech.2020.112653
état	Publié - 1 oct. 2020
Modification externe	Oui

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title = "Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses",

abstract = "Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).",

keywords = "COVID-19, Chikungunya virus, Coronavirus, Ebola virus, Natural products, Picornaviruses, Prohibitin, SARS-CoV-2, Zika virus, eIF4A",

author = "Nebigil, \{Canan G.\} and Christiane Moog and St{\'e}phan Vagner and Nadia Benkirane-Jessel and Smith, \{Duncan R.\} and Laurent D{\'e}saubry",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Masson SAS",

year = "2020",

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doi = "10.1016/j.ejmech.2020.112653",

language = "English",

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T2 - From traditional Chinese medicine to antiviral activity against coronaviruses

AU - Nebigil, Canan G.

AU - Moog, Christiane

AU - Vagner, Stéphan

AU - Benkirane-Jessel, Nadia

AU - Smith, Duncan R.

AU - Désaubry, Laurent

PY - 2020/10/1

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N2 - Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

AB - Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

KW - COVID-19

KW - Chikungunya virus

KW - Coronavirus

KW - Ebola virus

KW - Natural products

KW - Picornaviruses

KW - Prohibitin

KW - SARS-CoV-2

KW - Zika virus

KW - eIF4A

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DO - 10.1016/j.ejmech.2020.112653

M3 - Article

C2 - 32693294

AN - SCOPUS:85088007294

SN - 0223-5234

VL - 203

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 112653

ER -

Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

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