G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

Josué Carvalho; Jean Louis Mergny; Gilmar F. Salgado; João A. Queiroz; Carla Cruz

doi:10.1016/j.molmed.2020.05.002

G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

Josué Carvalho
, Jean Louis Mergny
, Gilmar F. Salgado
, João A. Queiroz
, Carla Cruz

Universidade da Beira Interior
Univ. Bordeaux
of Sciences

Résultats de recherche: Contribution à un journal › Article de révision › Revue par des pairs

Résumé

The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools (‘friends’, as healing anticancer drugs) and targets (‘foes’, within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.

langue originale	Anglais
Pages (de - à)	848-861
Nombre de pages	14
journal	Trends in Molecular Medicine
Volume	26
Numéro de publication	9
Les DOIs	https://doi.org/10.1016/j.molmed.2020.05.002
état	Publié - 1 sept. 2020
Modification externe	Oui

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title = "G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies",

abstract = "The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools ({\textquoteleft}friends{\textquoteright}, as healing anticancer drugs) and targets ({\textquoteleft}foes{\textquoteright}, within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.",

keywords = "G-quadruplex, anticancer strategy, aptamers, cell regulation, drug discovery, ligands",

author = "Josu{\'e} Carvalho and Mergny, \{Jean Louis\} and Salgado, \{Gilmar F.\} and Queiroz, \{Jo{\~a}o A.\} and Carla Cruz",

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year = "2020",

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doi = "10.1016/j.molmed.2020.05.002",

language = "English",

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T2 - The Role of the G-quartet in Anticancer Strategies

AU - Carvalho, Josué

AU - Mergny, Jean Louis

AU - Salgado, Gilmar F.

AU - Queiroz, João A.

AU - Cruz, Carla

PY - 2020/9/1

Y1 - 2020/9/1

N2 - The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools (‘friends’, as healing anticancer drugs) and targets (‘foes’, within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.

AB - The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools (‘friends’, as healing anticancer drugs) and targets (‘foes’, within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.

KW - G-quadruplex

KW - anticancer strategy

KW - aptamers

KW - cell regulation

KW - drug discovery

KW - ligands

U2 - 10.1016/j.molmed.2020.05.002

DO - 10.1016/j.molmed.2020.05.002

M3 - Review article

C2 - 32467069

AN - SCOPUS:85085353394

SN - 1471-4914

VL - 26

SP - 848

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JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 9

ER -

G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

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