Generation and characterization of an ordered lambda clone array for the 460-kb region surrounding the murine Xist sequence

C. Rougeulle; L. Colleaux; B. Dujon; P. Avner

doi:10.1007/BF00357001

Generation and characterization of an ordered lambda clone array for the 460-kb region surrounding the murine Xist sequence

C. Rougeulle
, L. Colleaux
, B. Dujon
, P. Avner

Institut Pasteur, Paris

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

The Xist sequence has several characteristics that make it a potential candidate for the X-inactivation center. To investigate the role of Xist and adjacent sequences lying within the X-inactivation center candidate region, a 460-kb region surrounding the murine Xist sequence has been arrayed in lambda contigs with a combination of IRS-PCR-based hybridization and YAC fragmentation. The orientation of the Xist sequence in relation to the telomere and centromere of the X Chromosome (Chr) has been established with this contig and shown to be inverted compared to that in human.

langue originale	Anglais
Pages (de - à)	416-423
Nombre de pages	8
journal	Mammalian Genome
Volume	5
Numéro de publication	7
Les DOIs	https://doi.org/10.1007/BF00357001
état	Publié - 1 juil. 1994
Modification externe	Oui

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10.1007/BF00357001

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title = "Generation and characterization of an ordered lambda clone array for the 460-kb region surrounding the murine Xist sequence",

abstract = "The Xist sequence has several characteristics that make it a potential candidate for the X-inactivation center. To investigate the role of Xist and adjacent sequences lying within the X-inactivation center candidate region, a 460-kb region surrounding the murine Xist sequence has been arrayed in lambda contigs with a combination of IRS-PCR-based hybridization and YAC fragmentation. The orientation of the Xist sequence in relation to the telomere and centromere of the X Chromosome (Chr) has been established with this contig and shown to be inverted compared to that in human.",

author = "C. Rougeulle and L. Colleaux and B. Dujon and P. Avner",

year = "1994",

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AU - Dujon, B.

AU - Avner, P.

PY - 1994/7/1

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N2 - The Xist sequence has several characteristics that make it a potential candidate for the X-inactivation center. To investigate the role of Xist and adjacent sequences lying within the X-inactivation center candidate region, a 460-kb region surrounding the murine Xist sequence has been arrayed in lambda contigs with a combination of IRS-PCR-based hybridization and YAC fragmentation. The orientation of the Xist sequence in relation to the telomere and centromere of the X Chromosome (Chr) has been established with this contig and shown to be inverted compared to that in human.

AB - The Xist sequence has several characteristics that make it a potential candidate for the X-inactivation center. To investigate the role of Xist and adjacent sequences lying within the X-inactivation center candidate region, a 460-kb region surrounding the murine Xist sequence has been arrayed in lambda contigs with a combination of IRS-PCR-based hybridization and YAC fragmentation. The orientation of the Xist sequence in relation to the telomere and centromere of the X Chromosome (Chr) has been established with this contig and shown to be inverted compared to that in human.

U2 - 10.1007/BF00357001

DO - 10.1007/BF00357001

M3 - Article

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ER -

Generation and characterization of an ordered lambda clone array for the 460-kb region surrounding the murine Xist sequence

Résumé

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