Genetic manipulation of insulin action and β-cell function in mice

Betty Lamothe; Bertrand Duvillié; Nathalie Cordonnier; Anne Baudry; Susan Saint-Just; Danielle Bucchini; Jacques Jami; Rajiv L. Joshi

doi:10.1023/A:1006813712567

Genetic manipulation of insulin action and β-cell function in mice

Betty Lamothe
, Bertrand Duvillié
, Nathalie Cordonnier
, Anne Baudry
, Susan Saint-Just
, Danielle Bucchini
, Jacques Jami
, Rajiv L. Joshi

Institut Cochin
INSERM U869

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such mutant mice will allow in the future to develop animal models in which the pathophysiologies resulting from polygenic defects might be reconstituted and studied in detail. Such animal models hopefully will lead to better understanding of complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM).

langue originale	Anglais
Pages (de - à)	161-168
Nombre de pages	8
journal	Molecular and Cellular Biochemistry
Volume	182
Numéro de publication	1-2
Les DOIs	https://doi.org/10.1023/A:1006813712567
état	Publié - 5 mai 1998
Modification externe	Oui

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10.1023/A:1006813712567

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title = "Genetic manipulation of insulin action and β-cell function in mice",

abstract = "Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such mutant mice will allow in the future to develop animal models in which the pathophysiologies resulting from polygenic defects might be reconstituted and studied in detail. Such animal models hopefully will lead to better understanding of complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM).",

keywords = "Animal models, Knockout mice, NIDDM, Transgenic mice",

author = "Betty Lamothe and Bertrand Duvilli{\'e} and Nathalie Cordonnier and Anne Baudry and Susan Saint-Just and Danielle Bucchini and Jacques Jami and Joshi, \{Rajiv L.\}",

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T1 - Genetic manipulation of insulin action and β-cell function in mice

AU - Lamothe, Betty

AU - Duvillié, Bertrand

AU - Cordonnier, Nathalie

AU - Baudry, Anne

AU - Saint-Just, Susan

AU - Bucchini, Danielle

AU - Jami, Jacques

AU - Joshi, Rajiv L.

PY - 1998/5/5

Y1 - 1998/5/5

N2 - Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such mutant mice will allow in the future to develop animal models in which the pathophysiologies resulting from polygenic defects might be reconstituted and studied in detail. Such animal models hopefully will lead to better understanding of complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM).

AB - Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such mutant mice will allow in the future to develop animal models in which the pathophysiologies resulting from polygenic defects might be reconstituted and studied in detail. Such animal models hopefully will lead to better understanding of complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM).

KW - Animal models

KW - Knockout mice

KW - NIDDM

KW - Transgenic mice

U2 - 10.1023/A:1006813712567

DO - 10.1023/A:1006813712567

M3 - Article

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AN - SCOPUS:0031917630

SN - 0300-8177

VL - 182

SP - 161

EP - 168

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

IS - 1-2

ER -

Genetic manipulation of insulin action and β-cell function in mice

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