Inference of DNA sequences from mechanical unzipping: An ideal-case study

V. Baldazzi; S. Cocco; E. Marinari; R. Monasson

doi:10.1103/PhysRevLett.96.128102

Inference of DNA sequences from mechanical unzipping: An ideal-case study

V. Baldazzi
, S. Cocco
, E. Marinari
, R. Monasson

Dipartimento di Fisica
University of Rome “Tor Vergata”
Center for Atomic-scale Materials Physics (CAMP)
Dipartimento di Fisica

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

28 Citations (Scopus)

Résumé

The performances of Bayesian inference to predict the sequence of DNA molecules from fixed-force unzipping experiments are investigated. We show that the probability of misprediction decreases exponentially with the amount of collected data. The decay rate is calculated as a function of biochemical parameters (binding free energies), the sequence content, the applied force, the elastic properties of a DNA single strand, and time resolution.

langue originale	Anglais
Numéro d'article	128102
journal	Physical Review Letters
Volume	96
Numéro de publication	12
Les DOIs	https://doi.org/10.1103/PhysRevLett.96.128102
état	Publié - 10 avr. 2006
Modification externe	Oui

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10.1103/PhysRevLett.96.128102

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title = "Inference of DNA sequences from mechanical unzipping: An ideal-case study",

abstract = "The performances of Bayesian inference to predict the sequence of DNA molecules from fixed-force unzipping experiments are investigated. We show that the probability of misprediction decreases exponentially with the amount of collected data. The decay rate is calculated as a function of biochemical parameters (binding free energies), the sequence content, the applied force, the elastic properties of a DNA single strand, and time resolution.",

author = "V. Baldazzi and S. Cocco and E. Marinari and R. Monasson",

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AB - The performances of Bayesian inference to predict the sequence of DNA molecules from fixed-force unzipping experiments are investigated. We show that the probability of misprediction decreases exponentially with the amount of collected data. The decay rate is calculated as a function of biochemical parameters (binding free energies), the sequence content, the applied force, the elastic properties of a DNA single strand, and time resolution.

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Inference of DNA sequences from mechanical unzipping: An ideal-case study

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