Molecular recognition of quadruplex DNA by quinacridine derivatives

M. P. Teulade-Fichou; C. Hounsou; L. Guittat; J. L. Mergny; P. Alberti; C. Carrasco; C. Bailly; J. M. Lehn; W. D. Wilson

doi:10.1081/NCN-120023016

Molecular recognition of quadruplex DNA by quinacridine derivatives

M. P. Teulade-Fichou
, C. Hounsou
, L. Guittat
, J. L. Mergny
, P. Alberti
, C. Carrasco
, C. Bailly
, J. M. Lehn
, W. D. Wilson

Collège de France
Collège de
INSERM U869
Lab. de Pharmacologie Anti-Tumorale
Georgia State University

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.

langue originale	Anglais
Pages (de - à)	1483-1485
Nombre de pages	3
journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	22
Numéro de publication	5-8
Les DOIs	https://doi.org/10.1081/NCN-120023016
état	Publié - 29 sept. 2003
Modification externe	Oui

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10.1081/NCN-120023016

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title = "Molecular recognition of quadruplex DNA by quinacridine derivatives",

abstract = "The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.",

keywords = "Dibenzophenanthrolines, Molecular recognition, Quadruplex DNA",

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T1 - Molecular recognition of quadruplex DNA by quinacridine derivatives

AU - Teulade-Fichou, M. P.

AU - Hounsou, C.

AU - Guittat, L.

AU - Mergny, J. L.

AU - Alberti, P.

AU - Carrasco, C.

AU - Bailly, C.

AU - Lehn, J. M.

AU - Wilson, W. D.

PY - 2003/9/29

Y1 - 2003/9/29

N2 - The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.

AB - The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.

KW - Dibenzophenanthrolines

KW - Molecular recognition

KW - Quadruplex DNA

UR - https://www.scopus.com/pages/publications/0141707926

U2 - 10.1081/NCN-120023016

DO - 10.1081/NCN-120023016

M3 - Article

C2 - 14565448

AN - SCOPUS:0141707926

SN - 1525-7770

VL - 22

SP - 1483

EP - 1485

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-8

ER -

Molecular recognition of quadruplex DNA by quinacridine derivatives

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