Multimodal AFM-IR nanospectroscopy and non-linear optical microscopy for detecting collagen matrix alterations

Jérémie Mathurin; Gaël Latour; Gervaise Mosser; Alexandre Dazzi; Marie Claire Schanne-Klein; Ariane Deniset-Besseau

doi:10.1039/d5an01298h

Multimodal AFM-IR nanospectroscopy and non-linear optical microscopy for detecting collagen matrix alterations

Jérémie Mathurin
, Gaël Latour
, Gervaise Mosser
, Alexandre Dazzi
, Marie Claire Schanne-Klein
, Ariane Deniset-Besseau

UMR 8000 CNRS
Université Paris-Sud 11
Université Paris-Saclay
Sorbonne Université

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.

langue originale	Anglais
Pages (de - à)	1881-1888
Nombre de pages	8
journal	Analyst
Volume	151
Numéro de publication	7
Les DOIs	https://doi.org/10.1039/d5an01298h
état	Publié - 30 mars 2026

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10.1039/d5an01298h

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abstract = "Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.",

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AU - Mathurin, Jérémie

AU - Latour, Gaël

AU - Mosser, Gervaise

AU - Dazzi, Alexandre

AU - Schanne-Klein, Marie Claire

AU - Deniset-Besseau, Ariane

PY - 2026/3/30

Y1 - 2026/3/30

N2 - Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.

AB - Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.

UR - https://www.scopus.com/pages/publications/105032164772

U2 - 10.1039/d5an01298h

DO - 10.1039/d5an01298h

M3 - Article

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SN - 0003-2654

VL - 151

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EP - 1888

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JF - Analyst

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Multimodal AFM-IR nanospectroscopy and non-linear optical microscopy for detecting collagen matrix alterations

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