New Straightforward Quinoline Synthesis from the Mannich Reaction of α-Ketohydrazones

Vincent Bailliez; Laurent El Kaim; Valérie Michaut

doi:10.1081/SCC-120027244

New Straightforward Quinoline Synthesis from the Mannich Reaction of α-Ketohydrazones

Vincent Bailliez
, Laurent El Kaim
, Valérie Michaut

Unité Chimie et Procédés

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

The addition of α-ketohydrazones to 2-acetamidobenzaldehyde proceeds efficiently in the presence of N-benzylpiperazine to afford in good to high yields the expected Mannich adducts; these are easily converted to quinoline derivatives under acidic conditions in a new Azo-Friedländer reaction.

langue originale	Anglais
Pages (de - à)	109-118
Nombre de pages	10
journal	Synthetic Communications
Volume	34
Numéro de publication	1
Les DOIs	https://doi.org/10.1081/SCC-120027244
état	Publié - 5 mars 2004
Modification externe	Oui

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10.1081/SCC-120027244

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@article{264acff247184c0eab2f22d41b44e4ce,

title = "New Straightforward Quinoline Synthesis from the Mannich Reaction of α-Ketohydrazones",

abstract = "The addition of α-ketohydrazones to 2-acetamidobenzaldehyde proceeds efficiently in the presence of N-benzylpiperazine to afford in good to high yields the expected Mannich adducts; these are easily converted to quinoline derivatives under acidic conditions in a new Azo-Friedl{\"a}nder reaction.",

keywords = "Azo-Friedl{\"a}nder reaction, Mannich reaction, Quinoline, α-Ketohydrazone",

author = "Vincent Bailliez and \{El Kaim\}, Laurent and Val{\'e}rie Michaut",

year = "2004",

month = mar,

day = "5",

doi = "10.1081/SCC-120027244",

language = "English",

volume = "34",

pages = "109--118",

journal = "Synthetic Communications",

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T1 - New Straightforward Quinoline Synthesis from the Mannich Reaction of α-Ketohydrazones

AU - Bailliez, Vincent

AU - El Kaim, Laurent

AU - Michaut, Valérie

PY - 2004/3/5

Y1 - 2004/3/5

N2 - The addition of α-ketohydrazones to 2-acetamidobenzaldehyde proceeds efficiently in the presence of N-benzylpiperazine to afford in good to high yields the expected Mannich adducts; these are easily converted to quinoline derivatives under acidic conditions in a new Azo-Friedländer reaction.

AB - The addition of α-ketohydrazones to 2-acetamidobenzaldehyde proceeds efficiently in the presence of N-benzylpiperazine to afford in good to high yields the expected Mannich adducts; these are easily converted to quinoline derivatives under acidic conditions in a new Azo-Friedländer reaction.

KW - Azo-Friedländer reaction

KW - Mannich reaction

KW - Quinoline

KW - α-Ketohydrazone

UR - https://www.scopus.com/pages/publications/1342281600

U2 - 10.1081/SCC-120027244

DO - 10.1081/SCC-120027244

M3 - Article

AN - SCOPUS:1342281600

SN - 0039-7911

VL - 34

SP - 109

EP - 118

JO - Synthetic Communications

JF - Synthetic Communications

IS - 1

ER -

New Straightforward Quinoline Synthesis from the Mannich Reaction of α-Ketohydrazones

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