New Trimethylaluminum-Induced Mannich-Type Reaction of Hydrazones

Laurent El Kaim; Laurence Grimaud; Yannick Perroux; Cornelia Tirla

doi:10.1021/jo0352272

New Trimethylaluminum-Induced Mannich-Type Reaction of Hydrazones

Laurent El Kaim
, Laurence Grimaud
, Yannick Perroux
, Cornelia Tirla

Unité Chimie et Procédés

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

12 Citations (Scopus)

Résumé

Trimethylaluminum addition to N-monoalkyl or N-monoaryl hydrazones followed by aldehyde addition leads to the formation of N-alkylated hydrazones in a new formal Mannich-type process. Addition compounds were also obtained in moderate yields with ketones. The mechanism as well as possible intermediates involved in the reaction are discussed.

langue originale	Anglais
Pages (de - à)	8733-8735
Nombre de pages	3
journal	Journal of Organic Chemistry
Volume	68
Numéro de publication	22
Les DOIs	https://doi.org/10.1021/jo0352272
état	Publié - 31 oct. 2003
Modification externe	Oui

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10.1021/jo0352272

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@article{e65db799e90b4ff098dc593ecbaa7b04,

title = "New Trimethylaluminum-Induced Mannich-Type Reaction of Hydrazones",

abstract = "Trimethylaluminum addition to N-monoalkyl or N-monoaryl hydrazones followed by aldehyde addition leads to the formation of N-alkylated hydrazones in a new formal Mannich-type process. Addition compounds were also obtained in moderate yields with ketones. The mechanism as well as possible intermediates involved in the reaction are discussed.",

author = "\{El Kaim\}, Laurent and Laurence Grimaud and Yannick Perroux and Cornelia Tirla",

year = "2003",

month = oct,

day = "31",

doi = "10.1021/jo0352272",

language = "English",

volume = "68",

pages = "8733--8735",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "22",

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TY - JOUR

T1 - New Trimethylaluminum-Induced Mannich-Type Reaction of Hydrazones

AU - El Kaim, Laurent

AU - Grimaud, Laurence

AU - Perroux, Yannick

AU - Tirla, Cornelia

PY - 2003/10/31

Y1 - 2003/10/31

N2 - Trimethylaluminum addition to N-monoalkyl or N-monoaryl hydrazones followed by aldehyde addition leads to the formation of N-alkylated hydrazones in a new formal Mannich-type process. Addition compounds were also obtained in moderate yields with ketones. The mechanism as well as possible intermediates involved in the reaction are discussed.

AB - Trimethylaluminum addition to N-monoalkyl or N-monoaryl hydrazones followed by aldehyde addition leads to the formation of N-alkylated hydrazones in a new formal Mannich-type process. Addition compounds were also obtained in moderate yields with ketones. The mechanism as well as possible intermediates involved in the reaction are discussed.

U2 - 10.1021/jo0352272

DO - 10.1021/jo0352272

M3 - Article

AN - SCOPUS:0142227931

SN - 0022-3263

VL - 68

SP - 8733

EP - 8735

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 22

ER -

New Trimethylaluminum-Induced Mannich-Type Reaction of Hydrazones

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