Site-Selective Palladium(II)-Catalyzed Methylene C(sp3)-H Diarylation of a Tropane Scaffold

Mayssa Zayene; Franck Le Bideau; Pascal Retailleau; Hichem Ben Jannet; Mouad Alami; Anis Romdhane; Samir Messaoudi

doi:10.1021/acs.joc.2c02081

Site-Selective Palladium(II)-Catalyzed Methylene C(sp³)-H Diarylation of a Tropane Scaffold

Mayssa Zayene
, Franck Le Bideau
, Pascal Retailleau
, Hichem Ben Jannet
, Mouad Alami
, Anis Romdhane
, Samir Messaoudi

Université Paris-Sud
Faculté des Sciences de Monastir
Institut de Chimie des Substances Naturelles

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

8 Citations (Scopus)

Résumé

A series of 2,4-di-arylated tropane derivatives was synthesized through a site-selective palladium-catalyzed β-C(sp3)-H di-arylation process. This type of structure has been scarcely reported in literature. They nevertheless represent an interesting class of biologically relevant molecules as illustrated by the observed activity at the micromolecular level of eight derivatives toward human colorectal cancer cell line HCT116.

langue originale	Anglais
Pages (de - à)	16399-16409
Nombre de pages	11
journal	Journal of Organic Chemistry
Volume	87
Numéro de publication	24
Les DOIs	https://doi.org/10.1021/acs.joc.2c02081
état	Publié - 16 déc. 2022
Modification externe	Oui

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Accès au document

10.1021/acs.joc.2c02081

Contient cette citation

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title = "Site-Selective Palladium(II)-Catalyzed Methylene C(sp3)-H Diarylation of a Tropane Scaffold",

abstract = "A series of 2,4-di-arylated tropane derivatives was synthesized through a site-selective palladium-catalyzed β-C(sp3)-H di-arylation process. This type of structure has been scarcely reported in literature. They nevertheless represent an interesting class of biologically relevant molecules as illustrated by the observed activity at the micromolecular level of eight derivatives toward human colorectal cancer cell line HCT116.",

author = "Mayssa Zayene and \{Le Bideau\}, Franck and Pascal Retailleau and Jannet, \{Hichem Ben\} and Mouad Alami and Anis Romdhane and Samir Messaoudi",

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T1 - Site-Selective Palladium(II)-Catalyzed Methylene C(sp3)-H Diarylation of a Tropane Scaffold

AU - Zayene, Mayssa

AU - Le Bideau, Franck

AU - Retailleau, Pascal

AU - Jannet, Hichem Ben

AU - Alami, Mouad

AU - Romdhane, Anis

AU - Messaoudi, Samir

PY - 2022/12/16

Y1 - 2022/12/16

N2 - A series of 2,4-di-arylated tropane derivatives was synthesized through a site-selective palladium-catalyzed β-C(sp3)-H di-arylation process. This type of structure has been scarcely reported in literature. They nevertheless represent an interesting class of biologically relevant molecules as illustrated by the observed activity at the micromolecular level of eight derivatives toward human colorectal cancer cell line HCT116.

AB - A series of 2,4-di-arylated tropane derivatives was synthesized through a site-selective palladium-catalyzed β-C(sp3)-H di-arylation process. This type of structure has been scarcely reported in literature. They nevertheless represent an interesting class of biologically relevant molecules as illustrated by the observed activity at the micromolecular level of eight derivatives toward human colorectal cancer cell line HCT116.

U2 - 10.1021/acs.joc.2c02081

DO - 10.1021/acs.joc.2c02081

M3 - Article

AN - SCOPUS:85143691798

SN - 0022-3263

VL - 87

SP - 16399

EP - 16409

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 24