Spectromicroscopy of boron in human glioblastomas following administration of Na2B12H11SH

B. Gilbert; L. Perfetti; O. Fauchoux; J. Redondo; P. A. Baudat; R. Andres; M. Neumann; S. Steen; D. Gabel; Delio Mercanti; M. Teresa Ciotti; P. Perfetti; G. Margaritondo; Gelsomina De Stasio

doi:10.1103/PhysRevE.62.1110

Spectromicroscopy of boron in human glioblastomas following administration of Na₂B₁₂H₁₁SH

B. Gilbert
, L. Perfetti
, O. Fauchoux
, J. Redondo
, P. A. Baudat
, R. Andres
, M. Neumann
, S. Steen
, D. Gabel
, Delio Mercanti
, M. Teresa Ciotti
, P. Perfetti
, G. Margaritondo
, Gelsomina De Stasio

ENAC-IIC-GEL
Paul Scherrer Institut
University of Bremen
Ev-K2-CNR Committee
Consiglio Nazionale delle Ricerche
Synchrotron Radiation Center

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

23 Citations (Scopus)

Résumé

The microdistribution and chemical state of boron in human tissue samples treated with Na₂B₁₂H₁₁SH (BSH) for boron neutron capture therapy (BNCT) are investigated. The products of tissue ashing can be identified by comparing X ray absorption near edge structure (XANES) spectra from ashed tissue with those from reference compounds. Samples of human glioblastoma from two patients administered with BSH and one patient not administered with BSH are analyzed in the MEPHISTO spetromicroscope. Results show the in vivo metabolism of BSH to a different chemical state.

langue originale	Anglais
Pages (de - à)	1110-1118
Nombre de pages	9
journal	Physical Review E
Volume	62
Numéro de publication	1 B
Les DOIs	https://doi.org/10.1103/PhysRevE.62.1110
état	Publié - 1 juil. 2000
Modification externe	Oui

Accès au document

10.1103/PhysRevE.62.1110

Contient cette citation

Gilbert, B., Perfetti, L., Fauchoux, O., Redondo, J., Baudat, P. A., Andres, R., Neumann, M., Steen, S., Gabel, D., Mercanti, D., Teresa Ciotti, M., Perfetti, P., Margaritondo, G., & De Stasio, G. (2000). Spectromicroscopy of boron in human glioblastomas following administration of Na₂B₁₂H₁₁SH. Physical Review E, 62(1 B), 1110-1118. https://doi.org/10.1103/PhysRevE.62.1110

@article{482236e5139843f89232c2b9fa9c99ed,

title = "Spectromicroscopy of boron in human glioblastomas following administration of Na2B12H11SH",

abstract = "The microdistribution and chemical state of boron in human tissue samples treated with Na2B12H11SH (BSH) for boron neutron capture therapy (BNCT) are investigated. The products of tissue ashing can be identified by comparing X ray absorption near edge structure (XANES) spectra from ashed tissue with those from reference compounds. Samples of human glioblastoma from two patients administered with BSH and one patient not administered with BSH are analyzed in the MEPHISTO spetromicroscope. Results show the in vivo metabolism of BSH to a different chemical state.",

author = "B. Gilbert and L. Perfetti and O. Fauchoux and J. Redondo and Baudat, \{P. A.\} and R. Andres and M. Neumann and S. Steen and D. Gabel and Delio Mercanti and \{Teresa Ciotti\}, M. and P. Perfetti and G. Margaritondo and \{De Stasio\}, Gelsomina",

year = "2000",

month = jul,

day = "1",

doi = "10.1103/PhysRevE.62.1110",

language = "English",

volume = "62",

pages = "1110--1118",

journal = "Physical Review E",

issn = "2470-0045",

publisher = "American Physical Society",

number = "1 B",

}

Gilbert, B, Perfetti, L, Fauchoux, O, Redondo, J, Baudat, PA, Andres, R, Neumann, M, Steen, S, Gabel, D, Mercanti, D, Teresa Ciotti, M, Perfetti, P, Margaritondo, G & De Stasio, G 2000, 'Spectromicroscopy of boron in human glioblastomas following administration of Na₂B₁₂H₁₁SH', Physical Review E, VOL. 62, Numéro 1 B, p. 1110-1118. https://doi.org/10.1103/PhysRevE.62.1110

TY - JOUR

T1 - Spectromicroscopy of boron in human glioblastomas following administration of Na2B12H11SH

AU - Gilbert, B.

AU - Perfetti, L.

AU - Fauchoux, O.

AU - Redondo, J.

AU - Baudat, P. A.

AU - Andres, R.

AU - Neumann, M.

AU - Steen, S.

AU - Gabel, D.

AU - Mercanti, Delio

AU - Teresa Ciotti, M.

AU - Perfetti, P.

AU - Margaritondo, G.

AU - De Stasio, Gelsomina

PY - 2000/7/1

Y1 - 2000/7/1

N2 - The microdistribution and chemical state of boron in human tissue samples treated with Na2B12H11SH (BSH) for boron neutron capture therapy (BNCT) are investigated. The products of tissue ashing can be identified by comparing X ray absorption near edge structure (XANES) spectra from ashed tissue with those from reference compounds. Samples of human glioblastoma from two patients administered with BSH and one patient not administered with BSH are analyzed in the MEPHISTO spetromicroscope. Results show the in vivo metabolism of BSH to a different chemical state.

AB - The microdistribution and chemical state of boron in human tissue samples treated with Na2B12H11SH (BSH) for boron neutron capture therapy (BNCT) are investigated. The products of tissue ashing can be identified by comparing X ray absorption near edge structure (XANES) spectra from ashed tissue with those from reference compounds. Samples of human glioblastoma from two patients administered with BSH and one patient not administered with BSH are analyzed in the MEPHISTO spetromicroscope. Results show the in vivo metabolism of BSH to a different chemical state.

U2 - 10.1103/PhysRevE.62.1110

DO - 10.1103/PhysRevE.62.1110

M3 - Article

C2 - 11088567

AN - SCOPUS:0034214952

SN - 2470-0045

VL - 62

SP - 1110

EP - 1118

JO - Physical Review E

JF - Physical Review E

IS - 1 B

ER -

Spectromicroscopy of boron in human glioblastomas following administration of Na2B12H11SH

Résumé

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Contient cette citation

Spectromicroscopy of boron in human glioblastomas following administration of Na₂B₁₂H₁₁SH