Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

Emmanuel Cazottes; Claire Rougeulle

doi:10.1016/j.stem.2020.08.008

Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

Emmanuel Cazottes
, Claire Rougeulle

Laboratoire de Probabilités et Modèles Aléatoires

Résultats de recherche: Contribution à un journal › Commentaire/débat

Résumé

In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

langue originale	Anglais
Pages (de - à)	352-353
Nombre de pages	2
journal	Cell Stem Cell
Volume	27
Numéro de publication	3
Les DOIs	https://doi.org/10.1016/j.stem.2020.08.008
état	Publié - 3 sept. 2020
Modification externe	Oui

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10.1016/j.stem.2020.08.008

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title = "Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade",

abstract = "In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.",

author = "Emmanuel Cazottes and Claire Rougeulle",

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year = "2020",

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T2 - Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

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AU - Rougeulle, Claire

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N2 - In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

AB - In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

U2 - 10.1016/j.stem.2020.08.008

DO - 10.1016/j.stem.2020.08.008

M3 - Comment/debate

C2 - 32888422

AN - SCOPUS:85089957041

SN - 1934-5909

VL - 27

SP - 352

EP - 353

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 3

ER -

Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

Résumé

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