Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

Mathieu Sassatelli; Fadoua Bouchikhi; Samir Messaoudi; Fabrice Anizon; Eric Debiton; Chantal Barthomeuf; Michelle Prudhomme; Pascale Moreau

doi:10.1016/j.ejmech.2005.10.004

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

Mathieu Sassatelli
, Fadoua Bouchikhi
, Samir Messaoudi
, Fabrice Anizon
, Eric Debiton
, Chantal Barthomeuf
, Michelle Prudhomme
, Pascale Moreau

Clermont-Auvergne University
Centre Jean Perrin

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.

langue originale	Anglais
Pages (de - à)	88-100
Nombre de pages	13
journal	European Journal of Medicinal Chemistry
Volume	41
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.ejmech.2005.10.004
état	Publié - 1 janv. 2006
Modification externe	Oui

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title = "Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives",

abstract = "In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.",

keywords = "Antiproliferative activities, Indigoids, Isoindigos",

author = "Mathieu Sassatelli and Fadoua Bouchikhi and Samir Messaoudi and Fabrice Anizon and Eric Debiton and Chantal Barthomeuf and Michelle Prudhomme and Pascale Moreau",

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AU - Sassatelli, Mathieu

AU - Bouchikhi, Fadoua

AU - Messaoudi, Samir

AU - Anizon, Fabrice

AU - Debiton, Eric

AU - Barthomeuf, Chantal

AU - Prudhomme, Michelle

AU - Moreau, Pascale

PY - 2006/1/1

Y1 - 2006/1/1

N2 - In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.

AB - In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.

KW - Antiproliferative activities

KW - Indigoids

KW - Isoindigos

U2 - 10.1016/j.ejmech.2005.10.004

DO - 10.1016/j.ejmech.2005.10.004

M3 - Article

C2 - 16330129

AN - SCOPUS:33244484119

SN - 0223-5234

VL - 41

SP - 88

EP - 100

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 1

ER -

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

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