Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

Gaëlle Le Bras; Abdallah Hamze; Samir Messaoudi; Olivier Provot; Pierre Benoît Le Calvez; Jean Daniel Brion; Mouâd Alami

doi:10.1055/s-2008-1072575

Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

Gaëlle Le Bras
, Abdallah Hamze
, Samir Messaoudi
, Olivier Provot
, Pierre Benoît Le Calvez
, Jean Daniel Brion
, Mouâd Alami

Université Paris-Saclay

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

55 Citations (Scopus)

Résumé

p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.

langue originale	Anglais
Numéro d'article	Z03208SS
Pages (de - à)	1607-1611
Nombre de pages	5
journal	Synthesis
Numéro de publication	10
Les DOIs	https://doi.org/10.1055/s-2008-1072575
état	Publié - 19 mai 2008
Modification externe	Oui

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10.1055/s-2008-1072575

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title = "Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes",

abstract = "p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.",

keywords = "Alkynes, Annulations, Isochromene, Isocoumarin, Microwave activation",

author = "\{Le Bras\}, Ga{\"e}lle and Abdallah Hamze and Samir Messaoudi and Olivier Provot and \{Le Calvez\}, \{Pierre Beno{\^i}t\} and Brion, \{Jean Daniel\} and Mou{\^a}d Alami",

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doi = "10.1055/s-2008-1072575",

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T1 - Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

AU - Le Bras, Gaëlle

AU - Hamze, Abdallah

AU - Messaoudi, Samir

AU - Provot, Olivier

AU - Le Calvez, Pierre Benoît

AU - Brion, Jean Daniel

AU - Alami, Mouâd

PY - 2008/5/19

Y1 - 2008/5/19

N2 - p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.

AB - p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.

KW - Alkynes

KW - Annulations

KW - Isochromene

KW - Isocoumarin

KW - Microwave activation

U2 - 10.1055/s-2008-1072575

DO - 10.1055/s-2008-1072575

M3 - Article

AN - SCOPUS:44949100255

SN - 0039-7881

SP - 1607

EP - 1611

JO - Synthesis

JF - Synthesis

IS - 10

M1 - Z03208SS

ER -

Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

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