Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis

M. C.D. Clochard; S. Brocchini

Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis

M. C.D. Clochard
, S. Brocchini

University College London
Centre for Polymer Therapeutics

Résultats de recherche: Contribution à un journal › Article de conférence › Revue par des pairs

1 Citation (Scopus)

Résumé

The synthesis of water-soluble polymers derived form cis-aconitic acid and polyethylene glycols (PEG) is described. Polymeric units that maintained a free carboxylic acid cis to an amide bond in the polymer mainchain degraded by a hydrolytic mechanism at pH 5.5 lysosome and 2.0 gut. In vitro biocompatibility assays indicated this polymer to be biocompatible. However, decarboxylation reactions during the synthesis were identified as the probable cause for the generation of nondegradable elements in the polymer mainchain.

langue originale	Anglais
Pages (de - à)	996-997
Nombre de pages	2
journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	41
Numéro de publication	1
état	Publié - 1 mars 2000
Modification externe	Oui
Evénement	The San Francisco Meeting - San Francisco, CA, USA Durée: 26 mars 2000 → 31 mars 2000

Contient cette citation

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title = "Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis",

abstract = "The synthesis of water-soluble polymers derived form cis-aconitic acid and polyethylene glycols (PEG) is described. Polymeric units that maintained a free carboxylic acid cis to an amide bond in the polymer mainchain degraded by a hydrolytic mechanism at pH 5.5 lysosome and 2.0 gut. In vitro biocompatibility assays indicated this polymer to be biocompatible. However, decarboxylation reactions during the synthesis were identified as the probable cause for the generation of nondegradable elements in the polymer mainchain.",

author = "Clochard, \{M. C.D.\} and S. Brocchini",

year = "2000",

month = mar,

day = "1",

language = "English",

volume = "41",

pages = "996--997",

journal = "American Chemical Society, Polymer Preprints, Division of Polymer Chemistry",

issn = "0032-3934",

number = "1",

note = "The San Francisco Meeting ; Conference date: 26-03-2000 Through 31-03-2000",

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TY - JOUR

T1 - Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis

AU - Clochard, M. C.D.

AU - Brocchini, S.

PY - 2000/3/1

Y1 - 2000/3/1

N2 - The synthesis of water-soluble polymers derived form cis-aconitic acid and polyethylene glycols (PEG) is described. Polymeric units that maintained a free carboxylic acid cis to an amide bond in the polymer mainchain degraded by a hydrolytic mechanism at pH 5.5 lysosome and 2.0 gut. In vitro biocompatibility assays indicated this polymer to be biocompatible. However, decarboxylation reactions during the synthesis were identified as the probable cause for the generation of nondegradable elements in the polymer mainchain.

AB - The synthesis of water-soluble polymers derived form cis-aconitic acid and polyethylene glycols (PEG) is described. Polymeric units that maintained a free carboxylic acid cis to an amide bond in the polymer mainchain degraded by a hydrolytic mechanism at pH 5.5 lysosome and 2.0 gut. In vitro biocompatibility assays indicated this polymer to be biocompatible. However, decarboxylation reactions during the synthesis were identified as the probable cause for the generation of nondegradable elements in the polymer mainchain.

M3 - Conference article

AN - SCOPUS:0033750875

SN - 0032-3934

VL - 41

SP - 996

EP - 997

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

IS - 1

T2 - The San Francisco Meeting

Y2 - 26 March 2000 through 31 March 2000

ER -

Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis

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