Synthesis of soluble polymers for medicine that degrade by intramolecular acid catalysis

Marie Claude Du Bois Clochard; Sheila Rankin; Stephen Brocchini

doi:10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m

Synthesis of soluble polymers for medicine that degrade by intramolecular acid catalysis

Marie Claude Du Bois Clochard
, Sheila Rankin
, Stephen Brocchini

University College London

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

Aqueous soluble polymers designed to rapidly degrade by an intramolecular assisted acid catalysed mechanism were prepared. Degradation studies at pH 5.5 and 2.0 exhibited a rapid first phase followed by a slower phase and incomplete degradation to macromonomeric species. The fast phase was attributed to repeat units containing a carboxylic acid pendent chain cis to an amide bond in the polymer mainchain and the slow phase by the absence of this free carboxylic acid moiety.

langue originale	Anglais
Pages (de - à)	853-859
Nombre de pages	7
journal	Macromolecular Rapid Communications
Volume	21
Numéro de publication	12
Les DOIs	https://doi.org/10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m
état	Publié - 18 août 2000
Modification externe	Oui

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10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m

Contient cette citation

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title = "Synthesis of soluble polymers for medicine that degrade by intramolecular acid catalysis",

abstract = "Aqueous soluble polymers designed to rapidly degrade by an intramolecular assisted acid catalysed mechanism were prepared. Degradation studies at pH 5.5 and 2.0 exhibited a rapid first phase followed by a slower phase and incomplete degradation to macromonomeric species. The fast phase was attributed to repeat units containing a carboxylic acid pendent chain cis to an amide bond in the polymer mainchain and the slow phase by the absence of this free carboxylic acid moiety.",

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AU - Clochard, Marie Claude Du Bois

AU - Rankin, Sheila

AU - Brocchini, Stephen

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Y1 - 2000/8/18

N2 - Aqueous soluble polymers designed to rapidly degrade by an intramolecular assisted acid catalysed mechanism were prepared. Degradation studies at pH 5.5 and 2.0 exhibited a rapid first phase followed by a slower phase and incomplete degradation to macromonomeric species. The fast phase was attributed to repeat units containing a carboxylic acid pendent chain cis to an amide bond in the polymer mainchain and the slow phase by the absence of this free carboxylic acid moiety.

AB - Aqueous soluble polymers designed to rapidly degrade by an intramolecular assisted acid catalysed mechanism were prepared. Degradation studies at pH 5.5 and 2.0 exhibited a rapid first phase followed by a slower phase and incomplete degradation to macromonomeric species. The fast phase was attributed to repeat units containing a carboxylic acid pendent chain cis to an amide bond in the polymer mainchain and the slow phase by the absence of this free carboxylic acid moiety.

U2 - 10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m

DO - 10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m

M3 - Article

AN - SCOPUS:23044518587

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VL - 21

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JO - Macromolecular Rapid Communications

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Synthesis of soluble polymers for medicine that degrade by intramolecular acid catalysis

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