The Mannich reaction of hydrazones: Improved reactivity under solvent-free conditions

L. El Kaïm; L. Gautier; L. Grimaud; L. M. Harwood; V. Michaut

doi:10.1039/b306242b

The Mannich reaction of hydrazones: Improved reactivity under solvent-free conditions

L. El Kaïm
, L. Gautier
, L. Grimaud
, L. M. Harwood
, V. Michaut

Unité Chimie et Procédés
University of Reading

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

17 Citations (Scopus)

Résumé

The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.

langue originale	Anglais
Pages (de - à)	477-479
Nombre de pages	3
journal	Green Chemistry
Volume	5
Numéro de publication	4
Les DOIs	https://doi.org/10.1039/b306242b
état	Publié - 1 janv. 2003
Modification externe	Oui

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10.1039/b306242b

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title = "The Mannich reaction of hydrazones: Improved reactivity under solvent-free conditions",

abstract = "The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.",

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T2 - Improved reactivity under solvent-free conditions

AU - El Kaïm, L.

AU - Gautier, L.

AU - Grimaud, L.

AU - Harwood, L. M.

AU - Michaut, V.

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N2 - The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.

AB - The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.

U2 - 10.1039/b306242b

DO - 10.1039/b306242b

M3 - Article

AN - SCOPUS:0242522295

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VL - 5

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EP - 479

JO - Green Chemistry

JF - Green Chemistry

IS - 4

ER -

The Mannich reaction of hydrazones: Improved reactivity under solvent-free conditions

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