The total synthesis of (±)-fortucine and a revision of the structure of kirkine

Aurélien Biechy; Shuji Hachisu; Béatrice Quiclet-Sire; Louis Ricard; Samir Z. Zard

doi:10.1002/anie.200704996

The total synthesis of (±)-fortucine and a revision of the structure of kirkine

Aurélien Biechy
, Shuji Hachisu
, Béatrice Quiclet-Sire
, Louis Ricard
, Samir Z. Zard

Laboratoire de Synthèse Organique
CNRS

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

53 Citations (Scopus)

Résumé

(Chemical Equation Presented) A molecular zipper: The total synthesis of the natural product fortucine relies on a radical cascade process initiated by the generation of a nitrogen-centered (amidyl) radical (see picture). The procedure is concise, and tin-free, as well as stereo- and regioselective. This synthesis has enabled the correction of the structure of kirkine, and the strategy represents a general and rapid entry into the galanthan framework.

langue originale	Anglais
Pages (de - à)	1436-1438
Nombre de pages	3
journal	Angewandte Chemie - International Edition
Volume	47
Numéro de publication	8
Les DOIs	https://doi.org/10.1002/anie.200704996
état	Publié - 8 févr. 2008
Modification externe	Oui

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10.1002/anie.200704996

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abstract = "(Chemical Equation Presented) A molecular zipper: The total synthesis of the natural product fortucine relies on a radical cascade process initiated by the generation of a nitrogen-centered (amidyl) radical (see picture). The procedure is concise, and tin-free, as well as stereo- and regioselective. This synthesis has enabled the correction of the structure of kirkine, and the strategy represents a general and rapid entry into the galanthan framework.",

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AU - Hachisu, Shuji

AU - Quiclet-Sire, Béatrice

AU - Ricard, Louis

AU - Zard, Samir Z.

PY - 2008/2/8

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AB - (Chemical Equation Presented) A molecular zipper: The total synthesis of the natural product fortucine relies on a radical cascade process initiated by the generation of a nitrogen-centered (amidyl) radical (see picture). The procedure is concise, and tin-free, as well as stereo- and regioselective. This synthesis has enabled the correction of the structure of kirkine, and the strategy represents a general and rapid entry into the galanthan framework.

KW - Alkaloids

KW - Cascade reactions

KW - Radical reactions

KW - Radicals

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The total synthesis of (±)-fortucine and a revision of the structure of kirkine

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