Unified, radical-based approach for the synthesis of spiroketals

Michiel De Greet; Samir Z. Zard

doi:10.1021/ol070488+

Unified, radical-based approach for the synthesis of spiroketals

Michiel De Greet
, Samir Z. Zard

Laboratoire de Synthèse Organique

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.

langue originale	Anglais
Pages (de - à)	1773-1776
Nombre de pages	4
journal	Organic Letters
Volume	9
Numéro de publication	9
Les DOIs	https://doi.org/10.1021/ol070488+
état	Publié - 26 avr. 2007
Modification externe	Oui

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10.1021/ol070488+

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@article{af91fc2ec57a4a50804d5ec49760518d,

title = "Unified, radical-based approach for the synthesis of spiroketals",

abstract = "Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.",

author = "\{De Greet\}, Michiel and Zard, \{Samir Z.\}",

year = "2007",

month = apr,

day = "26",

doi = "10.1021/ol070488+",

language = "English",

volume = "9",

pages = "1773--1776",

journal = "Organic Letters",

issn = "1523-7060",

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TY - JOUR

T1 - Unified, radical-based approach for the synthesis of spiroketals

AU - De Greet, Michiel

AU - Zard, Samir Z.

PY - 2007/4/26

Y1 - 2007/4/26

N2 - Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.

AB - Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.

U2 - 10.1021/ol070488+

DO - 10.1021/ol070488+

M3 - Article

C2 - 17391041

AN - SCOPUS:34248356404

SN - 1523-7060

VL - 9

SP - 1773

EP - 1776

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Unified, radical-based approach for the synthesis of spiroketals

Résumé

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