Xanthate-Mediated Incorporation of Quaternary Centers into Heteroarenes

Vincent L. Revil-Baudard; Jean Pierre Vors; Samir Z. Zard

doi:10.1021/acs.orglett.8b01299

Xanthate-Mediated Incorporation of Quaternary Centers into Heteroarenes

Vincent L. Revil-Baudard
, Jean Pierre Vors
, Samir Z. Zard

Laboratoire de Synthèse Organique
Bayer S.A.S.

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

The xanthate-mediated addition of tertiary alkyl radicals to heteroarenes enabled the easy functionalization of heteroaromatic rings as well as more decorated structures, such as marketed drugs or agrochemicals. This work provides a synthetic tool for efficiently exploring the chemical space by allowing late-stage diversification with a high tolerance toward functional groups.

langue originale	Anglais
Pages (de - à)	3531-3535
Nombre de pages	5
journal	Organic Letters
Volume	20
Numéro de publication	12
Les DOIs	https://doi.org/10.1021/acs.orglett.8b01299
état	Publié - 15 juin 2018
Modification externe	Oui

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10.1021/acs.orglett.8b01299

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title = "Xanthate-Mediated Incorporation of Quaternary Centers into Heteroarenes",

abstract = "The xanthate-mediated addition of tertiary alkyl radicals to heteroarenes enabled the easy functionalization of heteroaromatic rings as well as more decorated structures, such as marketed drugs or agrochemicals. This work provides a synthetic tool for efficiently exploring the chemical space by allowing late-stage diversification with a high tolerance toward functional groups.",

author = "Revil-Baudard, \{Vincent L.\} and Vors, \{Jean Pierre\} and Zard, \{Samir Z.\}",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = jun,

day = "15",

doi = "10.1021/acs.orglett.8b01299",

language = "English",

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journal = "Organic Letters",

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AU - Revil-Baudard, Vincent L.

AU - Vors, Jean Pierre

AU - Zard, Samir Z.

PY - 2018/6/15

Y1 - 2018/6/15

N2 - The xanthate-mediated addition of tertiary alkyl radicals to heteroarenes enabled the easy functionalization of heteroaromatic rings as well as more decorated structures, such as marketed drugs or agrochemicals. This work provides a synthetic tool for efficiently exploring the chemical space by allowing late-stage diversification with a high tolerance toward functional groups.

AB - The xanthate-mediated addition of tertiary alkyl radicals to heteroarenes enabled the easy functionalization of heteroaromatic rings as well as more decorated structures, such as marketed drugs or agrochemicals. This work provides a synthetic tool for efficiently exploring the chemical space by allowing late-stage diversification with a high tolerance toward functional groups.

U2 - 10.1021/acs.orglett.8b01299

DO - 10.1021/acs.orglett.8b01299

M3 - Article

C2 - 29856227

AN - SCOPUS:85048796434

SN - 1523-7060

VL - 20

SP - 3531

EP - 3535

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Xanthate-Mediated Incorporation of Quaternary Centers into Heteroarenes

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