Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang; Ling Qin; Samir Z. Zard

doi:10.1016/j.tet.2018.08.040

Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang
, Ling Qin
, Samir Z. Zard

Laboratoire de Synthèse Organique

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

7 Citations (Scopus)

Résumé

An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

langue originale	Anglais
Pages (de - à)	5804-5817
Nombre de pages	14
journal	Tetrahedron
Volume	74
Numéro de publication	40
Les DOIs	https://doi.org/10.1016/j.tet.2018.08.040
état	Publié - 4 oct. 2018
Modification externe	Oui

Accès au document

10.1016/j.tet.2018.08.040

Contient cette citation

@article{d2612548371442a7a017fb246a06dac1,

title = "Xanthate-mediated intermolecular alkylation of pyrazines",

abstract = "An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.",

keywords = "C-H functionalization of heteroaromatics, Minisci reaction, Pyrazines, Xanthates",

author = "Qi Huang and Ling Qin and Zard, \{Samir Z.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = oct,

day = "4",

doi = "10.1016/j.tet.2018.08.040",

language = "English",

volume = "74",

pages = "5804--5817",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "40",

}

TY - JOUR

T1 - Xanthate-mediated intermolecular alkylation of pyrazines

AU - Huang, Qi

AU - Qin, Ling

AU - Zard, Samir Z.

PY - 2018/10/4

Y1 - 2018/10/4

N2 - An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

AB - An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

KW - C-H functionalization of heteroaromatics

KW - Minisci reaction

KW - Pyrazines

KW - Xanthates

U2 - 10.1016/j.tet.2018.08.040

DO - 10.1016/j.tet.2018.08.040

M3 - Article

AN - SCOPUS:85053358891

SN - 0040-4020

VL - 74

SP - 5804

EP - 5817

JO - Tetrahedron

JF - Tetrahedron

IS - 40

ER -

Xanthate-mediated intermolecular alkylation of pyrazines

Résumé

Accès au document

Empreinte digitale

Contient cette citation