Zinc base assisted amination of 2-chloropyrimidines by aniline derivatives at room temperature

Lukas B. Delvos; Jeanne Marie Begouin; Corinne Gosmini

doi:10.1055/s-0030-1261220

Zinc base assisted amination of 2-chloropyrimidines by aniline derivatives at room temperature

Lukas B. Delvos
, Jeanne Marie Begouin
, Corinne Gosmini

CNRS

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

The amination of 2-chloropyrimidines was performed with several aniline derivatives in the presence of tolylzinc bromide as a base. The organozinc compound has a profound effect on the reactivity of the amines, so that the reaction takes place at room temperature. Further studies gave insight into the reaction mechanism and favor a nucleophilic substitution over a catalytic process.

langue originale	Anglais
Numéro d'article	B12811ST
Pages (de - à)	2325-2328
Nombre de pages	4
journal	Synlett
Numéro de publication	16
Les DOIs	https://doi.org/10.1055/s-0030-1261220
état	Publié - 12 sept. 2011
Modification externe	Oui

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10.1055/s-0030-1261220

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title = "Zinc base assisted amination of 2-chloropyrimidines by aniline derivatives at room temperature",

abstract = "The amination of 2-chloropyrimidines was performed with several aniline derivatives in the presence of tolylzinc bromide as a base. The organozinc compound has a profound effect on the reactivity of the amines, so that the reaction takes place at room temperature. Further studies gave insight into the reaction mechanism and favor a nucleophilic substitution over a catalytic process.",

keywords = "2-anilinopyrimidine, amination, heterocycles, nucleophilic aromatic substitution, zinc base",

author = "Delvos, \{Lukas B.\} and Begouin, \{Jeanne Marie\} and Corinne Gosmini",

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AU - Delvos, Lukas B.

AU - Begouin, Jeanne Marie

AU - Gosmini, Corinne

PY - 2011/9/12

Y1 - 2011/9/12

N2 - The amination of 2-chloropyrimidines was performed with several aniline derivatives in the presence of tolylzinc bromide as a base. The organozinc compound has a profound effect on the reactivity of the amines, so that the reaction takes place at room temperature. Further studies gave insight into the reaction mechanism and favor a nucleophilic substitution over a catalytic process.

AB - The amination of 2-chloropyrimidines was performed with several aniline derivatives in the presence of tolylzinc bromide as a base. The organozinc compound has a profound effect on the reactivity of the amines, so that the reaction takes place at room temperature. Further studies gave insight into the reaction mechanism and favor a nucleophilic substitution over a catalytic process.

KW - 2-anilinopyrimidine

KW - amination

KW - heterocycles

KW - nucleophilic aromatic substitution

KW - zinc base

UR - https://www.scopus.com/pages/publications/80053110024

U2 - 10.1055/s-0030-1261220

DO - 10.1055/s-0030-1261220

M3 - Article

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Zinc base assisted amination of 2-chloropyrimidines by aniline derivatives at room temperature

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